A recent study suggests that people who stop using blockbuster GLP-1 drugs like Wegovy and Mounjaro can put back on shed pounds much more quickly than those who halt traditional lifestyle plans.
Published data in a prominent health publication points out that while overweight people frequently drop about a fifth of their total mass while undergoing treatment, the weight returns at an estimated rate of nearly a kilo each month once they quit.
"Users using these drugs should be cognizant of the potential of rapid rebound weight gain when the therapy ends," stated lead investigator Dr. Susan Jebb.
This pace of recovery implies a return to pre-treatment mass within about one and a half years.
Weighing Therapies
The study, which examined 37 of studies involving over 9,000 of participants, contrasted the effects of these new drugs with other pills.
Scientists emphasize that individuals who shed pounds through lifestyle changes alone usually experience a less rapid weight regain—approximately 100 grams monthly—post-intervention.
Explaining the Rapid Regain
Experts believe the mode of action of the jabs accounts for the heightened rebound.
These medications copy a natural hormone called glucagon-like peptide-1, which helps regulate feelings of fullness.
"Sustained high doses of GLP-1 levels far above than the body's typical production might result in the body to generate a reduced amount of its endogenous GLP-1, and could lessen sensitivity to its effects," noted Dr. Adam Collins, a nutrition specialist.
"Withdrawal of this medication means appetite is unsuppressed, making excessive eating far more likely."
A Lifelong Disease?
The NHS recommend the injections for people with weight-linked health risks, accompanied by prescribed diet and exercise modifications.
Professionals say that, due to the high risk of relapse, the treatment might need to be ongoing.
This opinion is echoed by drug manufacturers, who state that the findings "highlight the chronic character of obesity," comparing it to managing conditions like high blood pressure.
Patient Testimonies
Individuals who have stopped the jabs explain a sudden resurgence of cravings.
"It was like a trigger that goes on and you become starving," recalled one woman.
The struggle is compounded if patients have not adopted lasting dietary or behavioural changes during therapy.
Significant Use
Figures indicate that a significant number of people in the UK have tried weight-loss jabs in the last 12 months, with demand being substantial.
- Adoption is greater among women than men.
- The 40s and 50s demographic shows the greatest usage rates.
- A large proportion obtain the drugs through private healthcare rather than public health services.
Ultimately, clinicians stress that while these medications are potent tools for weight loss, they are not a permanent fix and long-term success relies on integrated behavioural support.
